1986.09—1991.07 兰州医学院预防医学，学士

1998.09—2001.06  兰州医学院劳动卫生与环境卫生学，硕士

2004.09—2007.12  beat365体育官方网站中西医结合临床，博士

2003.12—2004.03  日本山形大学病理学，访问学者

2008.08—2009.08  加拿大Calgary University分子生物学，访问学者

1991.07— 1996.12  兰州医学院预防医学系，助教

1996.12— 2001.07  兰州医学院预防医学系，讲师

2001.07— 2004.11  兰州医学院beat365体育官方网站，副教授

2004.11— 2015.05  beat365体育官方网站，副教授

2015.05-至今     beat365体育官方网站，教授

研究方向：细胞和分子毒理学、纳米毒理学、毒性干预研究。

主持或参与科研项目：

1. LncRNA调控TGF-β1在纳米NiO致肺纤维化中的作用及分子机制（项目编号：31872757），国家自然科学基金-面上项目，主持。

2. LncRNA调控相关基因DNA甲基化在纳米氧化镍诱导肺纤维化中的表观遗传学机制研究（项目编号：21YF5FA113 ），甘肃省科技计划项目-重点研发计划，主持。

3.天然植物化学物联合治疗酒精性肝损伤的开发研究（项目编号：2017-RC-79），兰州市人才创新创业项目，主持。

4.纳米MnO₂致神经细胞损伤的分子机制研究，横向课题，主持。 

5.Loc101928316介导Wnt通路在致癌物MNNG诱发胃癌中的作用机制研究(项目编号：81803188)，国家自然科学基金-青年基金项目，参与。

6. TGF-β1介导的信号通路诱发EMT在纳米NiO致肺纤维化中的作用（项目编号：81602874），国家自然科学基金-青年基金项目，参与。

发表主要论文或专著:

[1] Jinfa Zheng, Jinyu Wang, Kun Li, Xin Qin, Sheng Li, Xuhong Chang, Yingbiao Sun. LncRNA AP000487.1 regulates PRKCB DNA methylation-mediated TLR4/ MyD88/NF-κB pathway in Nano NiO-induced collagen formation in BEAS-2B cells. Environ Toxicol, 2023, 38(11):2783-2796. （通讯作者）

[2] Jinfa Zheng, Jinyu Wang, Xin Qin, Kun Li, Qing Gao, Mengmeng Yang, Han Liu, Sheng Li, Xuhong Chang, Yingbiao Sun. LncRNA HOTAIRM1 involved in Nano NiO-induced pulmonary fibrosis via regulating PRKCB DNA methylation-mediated JNK/c-Jun pathway. Toxicol Sci, 2022, 190(1):64-78. doi: 10.1093/toxsci/kfac092. （通讯作者）

[3]Mengmeng Yang, Xuhong Chang, Qing Gao, Xuefeng Gong, Jinfa Zheng, Han Liu, Kun Li, Haibing Zhan, Xiaoxia Wang, Sheng Li, Xingchang Sun, Sanwei Feng, Yingbiao Sun*. LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway. Environ Toxicol, 2022, 37(5):1058-1070.（通讯作者）

[4]Qing Gao, Xuhong Chang, Mengmeng Yang, Jinfa Zheng, Xuefeng Gong, Han Liu, Kun Li, Xiaoxia Wang, Haibing Zhan, Sheng Li, Sanwei Feng, Xingchang Sun, Yingbiao Sun*. LncRNA MEG3 restrained pulmonary fibrosis induced by NiO NPs via regulating hedgehog signaling pathway-mediated autophagy. Environ Toxicol, 2022, 37(1):79-91.（通讯作者）

[5]Haibing Zhan, Xingchang Sun, Xiaoxia Wang, Qing Gao, Mengmeng Yang, Han Liu, Jinfa Zheng, Xuefeng Gong, Sanwei Feng, Xuhong Chang*, Yingbiao Sun*. LncRNA MEG3 Involved in NiO NPs-Induced Pulmonary Fibrosis via Regulating TGF-β1-Mediated PI3K/AKT Pathway. Toxicol Sci, 2021, 182(1):120-131.（通讯作者）

[6]Haibing Zhan, Xuhong Chang, Xiaoxia Wang, Mengmeng Yang, Qing Gao, Han Liu, Chengyun Li, Sheng Li, Yingbiao Sun*. LncRNA MEG3 mediates nickel oxide nanoparticles-induced pulmonary fibrosis via suppressing TGF-β1 expression and epithelial-mesenchymal transition process. Environ Toxicol, 2021, 36(6):1099-1110.（通讯作者）

[7]Qiong Zhang, Xuhong Chang, Xiaoxia Wang, Haibing Zhan, Qing Gao, Mengmeng Yang, Han Liu, Sheng Li , Yingbiao Sun*. A metabolomic-based study on disturbance of bile acids metabolism induced by intratracheal instillation of nickel oxide nanoparticles in rats. Toxicol Res, 2021,10(3):579-591.（通讯作者）

[8]Xiaoxia Wang, Xuhong Chang, Haibing Zhan, Chengyun Li, Qiong Zhang, Sheng Li, Yingbiao Sun*. Curcumin combined with Baicalin attenuated ethanol-induced hepatitis by suppressing p38 MAPK and TSC1/eIF-2α/ATF4 pathways in rats. 2021, Food Bioscience, 40:100851. （通讯作者）

[9]Xuhong Chang, Minmin Tian, Qiong Zhang, Fangfang Liu, Jinxia Gao, Sheng Li, Han Liu, Xiangbo Hou, Lei Li, Chengyun Li, Yingbiao Sun*. Grape seed proanthocyanidin extract ameliorates cisplatin-induced testicular apoptosis via PI3K/Akt/mTOR and endoplasmic reticulum stress pathways in rats. J Food Biochem, 2021, 45(8):e13825.（通讯作者）

[10]王晓霞, 占海兵, 高青, 张琼, 杨蒙蒙, 李盛, 常旭红, 孙应彪*. 姜黄素联合黄芩苷对乙醇诱导的大鼠胆汁淤积性肝损伤的保护作用研究. 毒理学杂志, 2021, 35(2):140-145.（通讯作者）

[11]王晓霞, 高青, 占海兵, 张琼, 杨蒙蒙, 李盛, 常旭红, 孙应彪*. 姜黄素联合黄芩苷对乙醇诱导大鼠肝细胞凋亡的干预作用研究. 毒理学杂志, 2020, 34(5): 362-369.（通讯作者）

[12]Xiaoxia Wang, Xuhong Chang, Haibing Zhan, Qiong Zhang, Chengyun Li, Qing Gao, Mengmeng Yang, Zhen Luo, Sheng Li, Yingbiao Sun*. Curcumin and Baicalin ameliorate ethanol-induced liver oxidative damage via the Nrf2/HO-1 pathway. J Food Biochem, 2020, 44(10):e13425.（通讯作者）

[13]Qiong Zhang, Xuhong Chang, Haibing Wang, Yunlan Liu, Xiaoxia Wang, Minmin Wu, Haibing Zhan, Sheng Li, and Yingbiao Sun*. TGF-β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro. Environ Toxicol, 2020, 35(4):419-429.（通讯作者）

[14]Xuhong Chang, Minmin Tian, Qiong Zhang, Jinxia Gao, Sheng Li, Yingbiao Sun*. Nano nickel oxide promotes epithelial-mesenchymal transition through transforming growth factor β1/smads signaling pathway in A549 cells. Environ Toxicol, 2020, 35 (12): 1308-1317.（通讯作者）

[15]Minmin Tian, Xuhong Chang, Qiong Zhang, Chengyun Li, Sheng Li, Yingbiao Sun*. TGF-β1 mediated MAPK signaling pathway promotes collagen formation induced by Nano NiO in A549 cells. Environ Toxicol, 2019, 34(6):719-727.（通讯作者）

[16]Xuhong Chang, Hongjun Zhao, Jinxia Gao, Lijuan Chen, An Zhu, Cheng Wang, Shu Yu, Xiaolan Ren, Pengfei Ge, Yingbiao Sun*. Pulmonary toxicity of exposure to nano nickel oxide. Micro & Nano Letters, 2018, 13(6):733-738.（通讯作者）

[17]Minmin Tian, Fangfang Liu, Han Liu, Qiong Zhang, Lei Li, Xiangbo Hou, Jianxin Zhao, Sheng Li, Xuhong Chang*, Yingbiao Sun*. Grape seed procyanidins extract attenuates Cisplatin-induced oxidative stress and testosterone synthase inhibition in rat testes. Syst Biol Reprod Med, 2018, 64(4): 246-259.（通讯作者）

[18]Shu Yu, Fangfang Liu, Chen Wang, Jingyi Zhang, An Zhu, Lingyue Zou, Aijie Han, Jin Li, Xuhong Chang, Yingbiao Sun*. Mol Med Rep, 2018, 17(2):3133-3139.（通讯作者）

[19]Han Aijie, Zou Lingyue, Gan Xiaoqin, Li Yu, Liu Fangfang, Chang Xuhong, Zhang Xiaotian, Tian Minmin, Li Sheng, Su Li*, Sun Yingbiao*. ROS generation and MAPKs activation contribute to the Ni-induced testosterone synthesis disturbance in rat Leydig cells. Toxicol lett, 2018, 290:36-45.（通讯作者）

[20]Fangfang Liu, Xuhong Chang, Minmin Tian, An Zhu, Linyue Zou, Aijie Han, Li Su, Sheng Li, Yingbiao Sun*. Nano NiO induced liver toxicity via activating the NF-κB signaling pathway in rats. Toxicol Res, 2017, 6(2):242-250.（通讯作者）  

[21]Xuhong Chang, Fangfang Liu, Minmin Tian, Hongjun Zhao, Aijie Han, Yingbiao Sun*. Nickel oxide nanoparticles induce hepatocyte apoptosis via activating endoplasmic reticulum stress pathways in rats. Environ Toxicol, 2017, 32(12): 2492-2499.（通讯作者）

[22]Xuhong Chang, An Zhu, Fangfang Liu, Lingyue Zou, Li Su, Shaokong Liu, Honghua Zhou, Yanyan Sun, Aijie Han, Yifan Sun, Su Li, Jin Li, Yingbiao Sun*. Nickel oxide nanoparticles induced pulmonary fibrosis via TGF-β1 activation in rats. Hum Exp Toxicol, 2017, 36(8):802-812.（通讯作者）

[23]Lingyue Zou, Li Su, Yifan Sun, Aijie Han, Xuhong Chang, An Zhu, Fangfang Liu, Jin Li, Yingbiao Sun*. Nickel sulfate induced apoptosis via activating ROS-dependent mitochondria and endoplasmic reticulum stress pathways in rat Leydig cells. Environ Toxicol, 2017, 32(7):1918-1926.（通讯作者）

[24]Xuhong Chang, An Zhu, Fangfang Liu, Lingyue Zou, Li Su, Sheng Li, Yingbiao Sun*. Role of NF-κB activation and Th1/Th2 imbalance in pulmonary toxicity induced by nano NiO. Environ Toxicol, 2017, 32(4):1354-1362.（通讯作者）

[25]Lingyue Zou, Li Su, Yifan Sun, Aijie Han, Xuhong Chang, An Zhu, Fangfang Liu, Jin Li, Yingbiao Sun*. Nickel sulfate induced apoptosis via activating ROS-dependent mitochondria and endoplasmic reticulum stress pathways in rat Leydig cells. Environ Toxicol, 2017, 32(7):1918-1926.（通讯作者）

[26]Xuhong Chang, An Zhu, Fangfang Liu, Lingyue Zou, Li Su, Sheng Li, Yingbiao Sun*. Role of NF-κB activation and Th1/Th2 imbalance in pulmonary toxicity induced by nano NiO. Environ Toxicol, 2017, 32(4):1354-1362.（通讯作者）

担任甘肃省卫生和计划生育委员会政策研究专家咨询委员会委员、甘肃省食品安全标准评审专家、中国毒理学会会员等。担任《毒理学杂志》和《中国妇幼健康研究》杂志编委，以及Nanotoxicology、Environmental Toxicology、Life Sciences、Environmental Science and Pollution Research、Human & Experimental Toxicology、毒理学杂志、生态毒理学报等期刊审稿专家。

科研项目获甘肃省教学成果奖省级二等奖1项，甘肃省科技进步奖和中国中西医结合学会科学技术奖4项，甘肃省医学科技奖和甘肃省教育厅科技进步奖6项。甘肃省青年教师成才奖，第十一届“挑战杯”甘肃省大学生课外学术科技作品竞赛优秀指导教师。2017、2018、2019、2020和2021年连续五年获得“甘肃省优秀硕士学位论文指导教师”称号。