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讲师

古雪岩

guxueyan

  • 职务

  • 职称

    讲师

  • 所在系所

    卫生毒理学系

  • 办公电话

  • E-mail

    guxy@lzu.edu.cn

基本情况

古雪岩,讲师,卫生毒理学系,博士。

学习经历

2007.09-2011.06,beat365体育官方网站,生命科学学院,生物技术专业,理学学士

2011.09-2018.06,beat365体育官方网站,生命科学学院,动物学专业,理学博士

工作经历

2018.07至今     beat365体育官方网站,讲师

目前承担课程

承担《预防医学》、《预防医学实验》和《医学科研设计和论文书写》等课程的讲授,其中《预防医学》为甘肃省精品课程。

主要科研成果

研究方向:

1. 重金属胁迫诱导神经毒性的分子机制;

2. 重金属胁迫诱导线粒体自噬的分子机制。

主持或参与科研项目:

1. 甘肃省自然科学基金,甘肃省科技计划项目(创新基地和人才计划)(20JR5RA248),纳米硒对镍致睾酮合成障碍的拮抗作用及其分子机制,2020-112022-10,在研,参与。

2. beat365体育官方网站中央高校基本科研业务费专项资金自由探索项目(自然科学类)新来校教师科研启动费项目(lzujbky-2019-7),线粒体铁硫簇生物合成在铅致神经毒性中的作用,2019-012020-12,已结题,主持。

3. beat365体育官方网站中央高校基本科研业务费专项资金自由探索项目(自然科学类)优秀研究生创新项目(lzujbky-2015-227),ATM对铅诱导的线粒体自噬的调控机制探究,2015-012016-06,已结题,主持。

4. 国家自然科学基金青年科学基金项目(31300941),ROSATM蛋白在亚精胺致线粒体自噬过程中的调控作用,2014-012016-12,已结题,参加。

发表主要论文或专著:

1. Caixia Wang1, Zhangyu Gu1, Xueyan Gu1, Xinyue Tan, Shuang Wang, Rui Zhang, Ruifen Li, Mingkun Sun, Chunyan Gui, Sheng Li, Yixing Ye, Jianhua Ma, Li Su*, Changhao Liang*. Nano-selenium attenuates mitochondrial-associated apoptosis via the PI3K/AKT pathway in nickel-induced hepatotoxicity in vivo and in vitro. Environmental Toxicology, 2022, 101-119.

2. Yongmei Qi1, Lin Ma1, Sajid Naeem, Xueyan Gu, Xijuan Chao, Cong Yuan, Dejun Huang. Pb induced mitochondrial fission of fibroblast cells via ATM activation, Journal of Hazardous Materials,2021, 416: 126177.

3. Caixia Wang1, Li Su1, Qiuling Mu, Xueyan Gu, Xuejun Guo*, Xuxia Wang*. Cost-effectiveness analysis of China domestic 13-valent pneumococcal conjugate vaccine for children under 5 years of age in mainland China. Human Vaccines & Immunotherapeutics, 2021, 12:1-8.

4. Qiannan E, Caixia Wang, Xueyan Gu, Xiaoqin Gan, Xiaotian Zhang, Shuang Wang, Jianhua Ma, Li Zhang, Rui Zhang, Li Su*. Competitive endogenous RNA (ceRNA) regulation network of lncRNA-miRNA-mRNA during the process of the nickel-induced steroidogenesis disturbance in rat Leydig cells. Toxicol in Vitro, 2020, 63:104721.

5. Xueyan Gu, Yongmei Qi*, Zengxiu Feng, Lin Ma, Ke Gao, Yingmei Zhang*. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol Lett, 2018, 291: 92-100.

6. Yuanzhen Xu1, Xueyan Gu1, Shoujiao Peng, Jianguo Fang, Yingmei Zhang, Dejun Huang, Jianjun Chen*, Kun Gao*. Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents. Eur J Med Chem, 2015, 94: 284-297.

7. Tingting Ge, Jianyuan Han, Yongmei Qi, Xueyan Gu, Lin Ma, Chen Zhang, Sajid Naeem, Dejun Huang*. The toxic effects of chlorophenols and associated mechanisms in fish, Aquat Toxicol, 2017, 184: 78-93.

8. Yongmei Qi1, Qian Qiu1, Xueyan Gu, Yihong Tian, Yingmei Zhang*. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts, Sci Rep-UK, 2016, 6: 24700.

9. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Dejun Huang*. Cadmium delays non-homologous end joining (NHEJ) repair via inhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and Ligase IV, Mutat Res-Fund Mol M, 2015, 779: 112-123.

10. Zhidan Niu, Wenya Zhang*, Xueyan Gu, Xiaoning Zhang, Yongmei Qi, Yingmei Zhang*. Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells, Environ Toxicol Phar, 2016, 45: 212-221.

11. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, Yingmei Zhang*. ROS act as a upstream signal to mediate cadmium-induced mitophagy in mouse brain, NeuroToxicology, 2015, 46: 19-24.

12. Yuanzhen Xu, Jianjun Chen, Ya Li, Shoujiao Peng, Xueyan Gu, Meng Sun, Kun Gao*, Jianguo Fang*. Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy, Org Biomol Chem, 2015, 13: 2634-2639.

13. Xue Wei, Yongmei Qi, Xiaoning Zhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun Huang, Yingmei Zhang*. Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway, Toxicol Mech Method, 2014, 24: 504-511.

 

社会兼职和社会服务

获奖情况

2021年beat365体育官方网站优秀共产党员;

2020年beat365体育官方网站“课程思政”示范课程讲课比赛三等奖;

2019年beat365体育官方网站第四届青年教师教学竞赛三等奖;

2018年beat365体育官方网站优秀毕业生;

2016年博士研究生国家奖学金。